Kratom ToleranceKratom is a common name for mitragyna speciosa, a tropical evergreen tree in the coffee family that is native to Southeast Asia. Kratom use is increasing in the United States, but there is no federal regulation and it is not currently considered a controlled substance at the federal level. However, some states have enacted their own regulation. Wisconsin, Indiana, Arkansas, Alabama, Vermont, Rhode Island and Tennessee have all made it illegal. As use is still relatively new in the United States, there is still a lot of research that is necessary to fully understand the drug and what kratom tolerance and dependence looks like.